Dinitrotoluene

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene.

Author:

Bruening, T. et al.

Year:

2001

Bibliographic source:

J. Occup. Environ. Med. 43, 610-615.

Reference 2

Reference Type:

secondary source

Title:

Nephrotoxicity and nephrocarcinogenicity of dinitrotoluene : New aspects to be considered.

Author:

Bruening, T. et al.

Year:

2002

Bibliographic source:

Reviews on Environmental Health 17, 163- 172.

Reference 3

Reference Type:

secondary source

Title:

Dinitrotoluene (isomers mixture), CAS No.: 25321-14-6

Author:

OECD SIDS

Year:

2004

Materials and methods

Type of study / information:

Health records

Principles of method if other than guideline:

A cohort of 161 underground miners who had been highly exposed to DNT in copper-mining industry of former German Democratic Republic was reinvestigated for signs of subclinical renal damage.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dinitrotoluene

EC Number:

246-836-1

EC Name:

Dinitrotoluene

Cas Number:

25321-14-6

Molecular formula:

C7H6N2O4

IUPAC Name:

Reaction mass of 1-methyl-2,4-dinitrobenzene and 2-methyl-1,3-dinitrobenzene

Details on test material:

- Name of test material (as cited in study report): 30% technical DNT (about 80% 2,4-DNT and 20% 2,6-DNT);
- Composition of test material, percentage of components: 30% , the composition of the remaining 70% of the explosives is not given
- Purity test date: no data

Method

Details on study design:

161 representative underground miners, that had all been highly exposed to DNT, and 19 miners with renal or urothelial cancer formerly highly exposed to explosives containing technical DNT out of a total group of 3000 underground miners in a plant in the former German Democratic Republic were reinvestigated for signs of subclinical renal damage. Studied parameters were alpha1-microglobulin and GST alpha as biomarkers for damage of the proximal tubule and GST pi for damage of the distal tubule.
The miners were grouped into 4 exposure categories according to types and duration of contact to DNT: skin contact (at least 5 hours per day) and inhalative exposure (no quantitative data; semi-quantitative procedure).

Exposure assessment:

estimated

Results and discussion

Results:

Results indicated a dose-dependent nephrotoxic effect directed to the tubular system with an increased incidence in renal or urothelial cancer cases (n=19) in contrast to the group of representative miners without cancer (n=161).