Registration Dossier
Registration Dossier
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EC number: 269-125-8 | CAS number: 68187-80-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A study was conducted according to OECD guideline 211, to evaluate the effect of the structurally similar amides, C12-18(even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) on the survival and reproduction of Daphnia magna for 21 days. Daphnia magna (10 per dose) were exposed to the test substance in a nominal concentration range of 0.010 - 1.0 mg/L for 21 days and the effects on survival and reproduction were determined three times per week. The 21 d NOEC and LOEC of the test substance for effects on reproduction and survival rates of Daphnia magna were 0.07 and 0.24 mg/L (based on the arithmetical mean measured concentrations of the nominal concentration of 0.1 and 0.32 mg/L) respectively. Based on read-across these values will be used for the assessment of HE Rape Oil, reaction product with diethanolamine.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.07 mg/L
Additional information
A study was conducted to evaluate the effect of the read across test substance amides, C12-18(even-numbered) and C18(unsatd.), N,N-bis(hydroxyethyl) on survival and reproduction of Daphnia magna according to OECD guideline 211.
Daphnia magna (10 per dose) were exposed to the test substance in a nominal concentration range of 0.010 - 1.0 mg/L for 21 days and the effects on survival and reproduction were determined three times per week.
Under the conditions of the study, the 21-d NOEC and LOEC of the read across test substance for effects on reproduction and survival rates of Daphnia magna were 0.07 and 0.24 mg/L (based on the arithmetical mean measured concentrations of the nominal concentration of 0.1 and 0.32 mg/L) respectively (Memmert U, 1995).
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