Registration Dossier
Registration Dossier
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EC number: 211-656-4 | CAS number: 681-84-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature HSDB data set. The original reference was not available for review and no further information is available.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 2008
Materials and methods
- Principles of method if other than guideline:
- Range finding study - assumed to be inhalation
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetramethyl orthosilicate
- EC Number:
- 211-656-4
- EC Name:
- Tetramethyl orthosilicate
- Cas Number:
- 681-84-5
- Molecular formula:
- C4H12O4Si
- IUPAC Name:
- tetramethyl silicate
- Details on test material:
- No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Data not available.
- Basis:
- other: Data not available.
- Time point:
- other: 0
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Other effects:
- Marked oedema and necrosis of the lid.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not possible to judge according to EU classification criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Very severe eye irritation leading to marked oedema and necrosis of the lid occurred in rabbits that were exposed to the methyl silicate vapour in an (assumed) inhalation range finding study. No further test details were available in the secondary source.
- Executive summary:
Very severe eye irritation leading to marked oedema and necrosis of the lid occurred in rabbits that were exposed to the undiluted methyl silicate in an inhalation range finding study. No further test details were available in the secondary source.
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