Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The result is sourced from secondary literature HSDB data set. The original reference was not available for review and no further information is available.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1986
Report Date:
2008

Materials and methods

Principles of method if other than guideline:
Range finding study - assumed to be inhalation
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
No data

Results and discussion

In vivo

Results
Irritation parameter:
other: Data not available.
Basis:
other: Data not available.
Time point:
other: 0
Score:
0
Max. score:
0
Reversibility:
not specified
Other effects:
Marked oedema and necrosis of the lid.

Applicant's summary and conclusion

Interpretation of results:
other: Not possible to judge according to EU classification criteria
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Very severe eye irritation leading to marked oedema and necrosis of the lid occurred in rabbits that were exposed to the methyl silicate vapour in an (assumed) inhalation range finding study. No further test details were available in the secondary source.
Executive summary:

Very severe eye irritation leading to marked oedema and necrosis of the lid occurred in rabbits that were exposed to the undiluted methyl silicate in an inhalation range finding study. No further test details were available in the secondary source.