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Long-term toxicity to aquatic invertebrates

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Testing for long-term toxicity to invertebrates is not considered necessary because:

  • Data for the structurally analogous substance tetraethyl orthosilicate (CAS 78-10-4), which shares the same hydrolysis product as the registered substance, indicate that short-term toxicity to invertebrates is low. Tetraethyl orthosilicate hydrolyses rapidly (half-life 4.4 h) to silicic acid and ethanol (CAS 64-17-5). The registered substance, tetramethyl orthosilicate, also hydrolyses rapidly (half-life <3 min at pH 4, 7 and 9 at approximately 20°C) but in this case to silicic acid and methanol (CAS 67-56-1).
  • The risk characterisation ratios (RCR) based on PNECaquatic (freshwater) derived from existing data for methanol are <1.