Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

Male rats given dimethyl terephthalate (DMPT, a structural analogue of DMIP) in the diet for 122 days showed no significant adverse effects of treatment, other than a slight decrease in body weight at 91 days. The NOAEL was 1% in the diet, with regard to parental toxicity in male and female rats. This is approximately equal to 400 mg/kg bw/d.


Short description of key information:
Dimethyl terephthalate (DMTP) was tested in a reproductive toxicity study and found not to result in adverse effects on fertility in males or females. DMTP is a structural analogue of DMIP, and is valid for reading-across to fill this data gap.

Justification for selection of Effect on fertility via oral route:
Valid experimental result

Effects on developmental toxicity

Description of key information
No adverse effects on foetal development occurred after Dimethyl terephthalate (DMTP, a structural analogue of DMIP), was administered at 1000 mg/kg bw/d to Wistar rats in an OECD 414 developmental toxicity study.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

Dimethyl terephthalate (DMTP, a structural analogue of DMIP) was administered at 1000 mg/kg bw/d

to female Wistar rats during gestation days 7 to 16. Treatment had no adverse effect on either general maternal health or intrauterine development. The NOAEL was 1000 mg/kg body weight/d for both maternal toxicity and embryotoxicity/foetoxicity. Data can be read-across to dimethyl isophthalate from DMTP, based on common functional groups. The substances are isomers. The similarities in structure are likely to apply to metabolites as well, with DMIP breaking down to isophthalic acid, just as DMTP is known to break down to terephthalic acid; these are isomers. Similar structures and similar break-down products for the two substances is the basis for the reading-across of data for this endpoint. This is adequate to fulfill the information requirements of Annex IX, to be the basis for classification and labelling decisions, and for risk assessment.

Justification for selection of Effect on developmental toxicity: via oral route:
Valid experimental results

Justification for classification or non-classification

No adverse effects to reproduction were observed in experimental studies with a structural analogue, dimethyl terephthalate. The read-across approach has been determined to be valid. There is no basis for classification and labelling for reproductive effects.

Additional information