Registration Dossier
Registration Dossier
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EC number: 215-951-9 | CAS number: 1459-93-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Dimethyl terephthalate, an analogue of dimethyl isophthalate, is rapidly absorbed and excreted. No significant quantities of the compound accumulate in the tissues following single or repeated oral, intratracheal and dermal administration or single ocular administration to laboratory animals.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
The toxicokinetics of DMTP, a structural analogue of DMIP, was investigated using radiolabeled material and administered to rats and rabbits via the oral, dermal, intratracheal and ocular routes. DMTP is rapidly absorbed and excreted after oral exposure, whether given as a single or repeated dose. At 48 hours after single dosing, 83 to 95% of the substance is excreted in urine and faeces. After multiple oral dosing over 5 days, over 91 -95% of the dose is excreted. DMTP applied to the skin was found to be absorbed, although the study design did not allow for quantitation of the amount removed from the skin after 24 hours. No conclusions can be drawn concerning intratracheal instillation, as less than 1% recovery was observed, likely due to inadequate suspension of the DMTP or difficulties in dosing. Approximately 30% of the material given via ocular administration was absorbed and excreted. No significant transfer to organs was observed. Water-soluble metabolites were recovered from urine and faeces. Excretion was primarily through urine. These data suggest rapid excretion and no significant bioaccumulation of DMTP, and, by analogy, of DMIP. The two substances are structural analogues (isomers) with common functional groups. The two substances have similar physico-chemical properties, low acute mammalian toxicity, and similar genotoxicity profiles. Both are biodegradable in the environment, and have comparable acute aquatic toxicity values. Data on DMTP are adequate to fulfill the information requirements of Annex IX for DMIP, to be the basis for classification and labelling decisions, and for risk assessment.
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