Registration Dossier
Registration Dossier
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EC number: 215-951-9 | CAS number: 1459-93-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Dimethyl isophthalate is not a sensitiser in the murine local lymph node assay, nor in the guinea pig maximization test and human repeat insult patch testing. These data, taken together, are strong evidence that the substance is nonsensitising. The substance was used as a nonsensitiser in numerous validation studies of the LLNA method.
Migrated from Short description of key information:
The substance is non-sensitising in the LLNA.
Justification for selection of skin sensitisation endpoint:
experimental data generated by an experienced laboratory
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Dimethyl isophthalate is not a sensitiser in the murine local lymph node assay, nor in the guinea pig maximization test and human repeat insult patch testing. These data indicate that the substance is nonsensitising. Therefore, the substance is not classified as a sensitiser according to Regulation EC No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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