Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The Magnusson & Kligman test performed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate showed a significant potential to cause skin sensitisation.


Migrated from Short description of key information:
One skin sensitisation study (Maximization test) was performed with Guinea Pigs according to OECD 406. The intradermal induction was performed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate at 1% in Oleum arachidis and the epidermal induction was performed with the undiluted test item.
The challenge was perfomed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate at 50% in vaseline. After 24 hours 14 out of 20 animals were sensitised and after 48 hours all animals showed a skin sensitising effect.

Justification for classification or non-classification

- skin sensitisation:

Based on the above stated assessment of the skin sensitisation potential of tris(oxyranylmethyl)benzene-1,2,4 -tricarboxylate (100% of the animals sensitized in Magnuson & Kligman test) the substance needs to be classified as R43 (May cause sensitisation by skin contact) according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and Skin Sens. 1 (H317: may cause an allergic skin reaction) according CLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.

- respiratory sensitisation:

As no data on respiratory sensitization is available for tris(oxyranylmethyl)benzene-1,2,4 -tricarboxylate a classification is not possible according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.

Categories Display