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Description of key information

The test item is degraded by hydrolysis.

Key value for chemical safety assessment

Half-life for hydrolysis:
101 h
at the temperature of:
20 °C

Additional information

Hydrolysis of tris(oxiranylmethyl)benzene-1,2,4 -tricarboxylate at about 10 mg a.i./L was studied in the dark at 20, 40 and 50 ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9.

The experiment was conducted in accordance with the EEC directive 92/69, Annex V, Part C, Degradation, C.7 “Hydrolysis as a Function of pH”, December 1992 and

OECD Guidelines for Testing of Chemicals, Guideline No. 111, ”Hydrolysis as a Function of pH”, adopted April 2004 and in compliance with the GLP standards.

 The OECD Principles of Good Laboratory Practice (as revised in 1997) ENV/MC/CHEM(98)17

Chemikaliengesetz ('Chemicals Act') der Bundesrepublik Deutschland (ChemG), Anhang 1 ('Annex 1'), 2008

Directive 2004/10/EC of(Official Journal No. L 50/44).

Samples were analysed by HPLC (UV/VIS-detector).

The test item is degraded by hydrolysis. The half life of reaction at 20°C were determined to be 101 h at pH 4, 101 h at pH 7 and 7 h at pH 9. From chemical structure and literature reference it was assumed that 1,2,4-benzenetricarboxylic acid is the hydrolysis product.

However, the compound was not clearly identified in solution which might be a consequence of the instability of the metabolite under the test conditions.