Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-638-7 | CAS number: 7237-83-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate is mutagenic in vitro, which is not surprising considering the three epoxy groups and knowing that most of the epoxy compounds are known to be mutagenic under in vitro conditions. However, negative results were obtained in two in vivo studies; an in vivo micronucleus study performed with rats and an in vivo germ-cell cytogenetics study performed with mice. Tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate is therefore considered as negative for mutagenicity.
Short description of key information:
tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate was found to be mutagenic in vitro in a bacterial reverse mutation assay performed according to OECD 471 as well as in mammalian cell gene mutation assay at the Thymidine kinase (tk)-Locus performed according to OECD 476.
However, tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate was found to be not clastogenic in vivo in a micronucleus assay in rat bone marrow cells performed according to OECD 474 and in a mammalian germ-cell cytogenetics assay in mice performed according to OECD 483.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the above stated assessment of the genotoxic potential tris(oxyranylmethyl)benzene-1,2,4-tricarboxylate (Ames test positive,in vitro mammalian cell gene mutation test positive, in vivo mammalian micronucleus test in bone marrow cells negative and in vivo spermatogonia chromosome aberration test negative) the substance is deemed non-genotoxic and accordingly does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according to CLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
