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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Comparative acute toxicity and primary irritancy of various classes of amines
Author:
Myers RC and Ballantyne B
Year:
1997
Bibliographic source:
TOXIC SUBST MECH, 16 151-193.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminopropyldiethylamine
EC Number:
203-236-4
EC Name:
3-aminopropyldiethylamine
Cas Number:
104-78-9
Molecular formula:
C7H18N2
IUPAC Name:
(3-aminopropyl)diethylamine
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: 3-5 months
- Weight at study initiation: 2-3kg
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): ad libitum commercialdiet
- Water (e.g. ad libitum): ad libitum municipal water
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Fur was carefully removed from the ventral skin, using an electric clipper. Test substance was applied and impervious plastic sheeting was wrapped around the trunk and secured.
The rabbit was immobilized into a restraining apparatus for 24 hours.
Duration of exposure:
24 hours
Doses:
No data
No. of animals per sex per dose:
5 males
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations : daily
- Weighing D1, 14
- Necropsy of survivors performed: yes
Statistics:
method of Thompson, tables of Weil

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
0.64 mL/kg bw
95% CL:
0.39 - 1.04
Sex:
male
Dose descriptor:
LD50
Effect level:
524 mg/kg bw
95% CL:
320 - 853
Remarks on result:
other: based on a density of 0.82
Mortality:
time to death=1d
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Conclusions:
The dermal LD50 was 524 mg/kg in male rabbits.
Executive summary:

The Acute dermal toxicity of 3 -aminopropyldiethylamine was evaluated in five male New Zealand white rabbits. The test substance was applied under an impervious plastic sheeting wrapped around the trunk and secured. The rabbit was then immobilized into a restraining apparatus for 24 hours. Animals were observed during 14 days.

No other data is available. Under these experimental conditions, the dermal LD50 was 0.64 ml/kg (524 mg/kg) in male rabbits.