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Description of key information

No data on toxicokinetics, metabolism and distribution are available for 3-aminopropyldiethylamine. Based on its physico-chemical properties, 3-aminopropyldiethylamine is expected to be well absorbed by the respiratory and gastro-intestinal tracts and through the skin. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100
Absorption rate - inhalation (%):
100

Additional information

There is no toxicokinetics, metabolism and distribution data available on3-aminopropyldiethylamine. Therefore, the assessment of the toxicokinetics of 3-aminopropyldiethylamine is based on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c.

Molecular weight: 130.23 g/mole

Water solubility: miscible

Partition coefficient log Kow = 0.36

ABSORPTION

Oral route

According to the REACH Guidance, the physicochemical characteristics of 3-aminopropyldiethylamine and the molecular mass are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is supported by the mortality observed in the acute oral toxicity study in rats (BASF, 1981).

Therefore, the oral absorption of 3-aminopropyldiethylamine can be assumed to be 100% for risk assessment.

Inhalation route

According to the REACH Guidance, the physicochemical characteristics of 3-aminopropyldiethylamine and the molecular mass are in a range suggestive of absorption as such from the respiratory subsequent to inhalation exposure.

Therefore, the inhalation absorption of 3-aminopropyldiethylamine can be assumed to be 100% for risk assessment.

Dermal absorption

According to the REACH Guidance, the n-Octanol/water partition coefficient, the water solubility and molecular weight of 3-aminopropyldiethylamine are in ranges which favour dermal absorption. This assumption is supported by the mortality observed in the acute dermal toxicity study in rabbits (Myers & Ballantyne, 1997).

DISTRIBUTION and METABOLISM

According to the REACH Guidance, as a small molecule a wide distribution of 3-aminopropyldiethylamine is expected.

N-oxide formation and excretion of both freebase and N-oxide forms, with a small quantity undergoing dealkylation, appears to be the major route of excretion for the lower molecular weight tertiary amines.

ELIMINATION

According to the REACH Guidance, the n-Octanol/water partition coefficient is not suggestive of accumulation of unchanged 3-aminopropyldiethylamine in fatty tissues subsequent to absorption.