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Administrative data

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Description of key information

Information selected for the toxicokinetic assessment is made up of test study data. Based upon the selected data Methylenebis (dibutyldithiocarbamate) is expected to have low bioaccumulation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The following information on Methylenebis (dibutyldithiocarbamate) was used for the assessment:

 

Physical form: viscous liquid

Water solubility: 0.247 mg/l at 20 ± 5 ºC

Log Pow: 8.42 at 35 ºC

Vapour pressure: <0.13E-08 Pa

Boiling point: Does not boil prior to decomposition (≥ 250 ºC)

Molecular weight: 422.7784

Hydrogen bond donors: 0

Hydrogen bond acceptors: 0

 

Based upon the above information Methylenebis (dibutyldithiocarbamate), is not expected to be absorbed via the oral route in accordance with Lipinski's rule of five. The low water solubility and high Log Pow of the substance indicate that Methylenebis (dibutyldithiocarbamate) is not easily absorbed in the body. No information is currently available on possible degradation products produced in the gastrointestinal tract.

 

During acute and repeat dose studies no systemic or local effects were noted at doses which humans are likely to come into contact. An increase in liver weight and decrease in body weight was noted in females receiving between 314.0 - 398.6 mg/kg bw/day in the repeat dose toxicity study. Effects on males were only noted at the 1278.5 - 1957.0 mg/kg bw/day dose level. The increase in absolute and relative liver weight indicates that the liver is the main site of metabolism. No observations on excretion were noted, it is therefore not possible to determine the main route of excretion. If the liver is indeed the main site of metabolism it is likely that excretion will be through the bile (feaces).