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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The 48-Hour EC50 of methylenbis(dibutyldithiocarbamate) (centrifuged test media) to daphnia magna  is greater than 0.052 mg/L (mean measured) and correspondingly the NOEC was 0.052 mg/L (Safepharm Laboratories, 2004). 
Methylenbis(dibutyldithiocarbamate) is known to possess a low water solubility (0.243 mg/l at 20 ± 5 ºC). In the absence of any evidence of toxicity, and taking into consideration the difficulties in water solubility, it is considered that no evidence of toxicity is seen at the limit of solubility.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
0.052 mg/L

Additional information

In an OECD 204 study, conducted to GLP, the 48-HourEC50 of methylenbis(dibutyldithiocarbamate) (centrifuged test media) todaphnia magna is greater than 0.052 mg/L (mean measured) and correspondingly the NOEC was 0.052 mg/L (Safepharm Laboratories, 2004).

No mortality was observed during the test. The test was conducted using dimethylforamide to pre-dissolve the test material before dilution in test media. When analysed test concentrations were far lower than what was theoretically created, indicating that there were difficulties stemming from water solubility of the test material. methylenbis(dibutyldithiocarbamate) is known to possess a low water solubility (0.243 mg/l at 20 ± 5 ºC). In the absence of any evidence of toxicity, and taking into consideration the difficulties in water solubility, it is considered that no evidence of toxicity is seen at the limit of solubility.