Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-117-2 | CAS number: 133-66-4
assessment used to read across:Not irritating on rabbit skin (OECD 404)Not irritating in rabbit eyes (OECD 405)
Erythema score after 24, 48 and 72 h (animal1/2/3/4/5/6)
Edema score after 24, 48 and 72 h (animal1/2/3/4/5/6)
All effects were fully reversible within 7 days (all scores: 0.0). There was no staining of the treated skin.
Findings animal 1/2/3 (undiluted test substance, eyes not washed out):
Findings animal 4/5/6 (undiluted test substance, eyes washed out):
FAT 65'023/L was found to cause mild irritation when applied to the rabbit eye mucosa.
In a primary dermal irritation study with a close structural analogue (CAS 16090 -02 -1), 6 New Zealand White rabbits were dermally exposed to 0.5 mL of test substance for 24 hours under occlusive conditions. Animals then were observed for 7 days. Irritation was scored by the method of Draize as described in the OECD guideline 404. The mean score for the 24, 48 and 72 h reading for erythema was 1.4 and for edema was 0.4. The skin reactions observed were fully reversible until the end of the observation period on day 7. In this study, the tested substance CAS 16090-02-1) is not a dermal irritant.
Due to the consistent observation that the substance does not induce skin irritation it is concluded that the substance CAS 133 -66 -4 is also not irritating to skin and has not to be classified as skin irritation.
An eye irritation test was performed with three New Zealand White rabbits on a close structural analogue (CAS 16090 -02 -1). Eyes were left unwashed after application of 0.1 g test substance and the animals were observed 7 days. The mean scores for the 24, 48 and 72 h reading for iritis and cornea opacity were 0 at any reading time point. For conjunctivae redness the mean score was 0.3 and for conjunctivae chemosis 0.1. The eye reactions observed were fully reversible within 72 and 48 hours, respectively. In this study the family member (CAS 16090-02-1) is not an eye irritant.
Due to the consistent observation that the substance does not induce eye irritation it is concluded that the substance CAS 133 -66 -4 is not irritating to eye and has not to be classified as eye irritant.
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the category members are not considered to be classified for skin and eye irritation/corrosion under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the category members are not considered to be classified for skin and eye irritation/corrosion under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again