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EC number: 205-117-2 | CAS number: 133-66-4
Up to the highest investigated dose, neither a significant and reproducible increase of the number of revertants was found in any strain as compared to the solvent control nor a concentration dependent enhancement of the revertant number exists. The presence of liver microsomal activation did not influence these findings.
In strain TA 98 a slight increase in revertant colony numbers was observed at 5000.0 µg/plate in the presence of metabolic activation in experiment II. This effect is considered being irrelevant since it could not be reproduced in the independent experiment. Appropriate reference mutagens were used as positive controls and showed a distinct increase in induced revertant colonies.
In conclusion, it can be stated that during the described mutagenicity test and under the experimental conditions reported, the test article did not induce point mutations by base pair changes or frameshifts in the genome of the strains used.
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