Registration Dossier

Diss Factsheets

Administrative data

Description of key information

No test was performed on skin and eye irritation/corrosion, as the substance is a gas. Nevertheless, BF3 is considered as corrosive to skin and irritating to eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Clinical signs of respiratory distress were observed during short term and long term toxicity studies with BF3 or BF3 dihydrate, even at low concentrations. Eye irritation was observed (lacrimation), and no sign of skin irritation was observed during those studies. Considering that BF3 is hydrolyzed when in contact with water, it was expected that no or few skin irritation was present, and that a slight eye irritation could be observed.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

According to EU Regulation (EC) N0. 1272/2008 (CLP), the substance is classified as corrosive to skin, category 1 A, and eye damage category 1 (H314 And H318). A STOT Single Exp. 3 (H335) is proposed for respiratory tract irritation.

According to EU directive 67/548/EEC, the substance is corrosive C, R35) . In addition, it is proposed to classify BF3 as irritating for respiratory tract (R37).