Registration Dossier
Registration Dossier
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EC number: 231-569-5 | CAS number: 7637-07-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientiffically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 13319-75-0
- Cas Number:
- 13319-75-0
- IUPAC Name:
- 13319-75-0
- Reference substance name:
- boron trifluoride dihydrate
- IUPAC Name:
- boron trifluoride dihydrate
- Details on test material:
- - Name of test material (as cited in study report): borfluorid-Dihydrat
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- A standardized animal laboratory diet was used.
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- The test substance was administered in concentrations of 2.15, 3.16, 4.64 and 6.81% (V/V)
- Doses:
- 351, 515, 756, 1110 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 326 mg/kg bw
- Remarks on result:
- other: original value : ca. 200 ul/kg
- Mortality:
- 351 mg/kg: 6/20 after 14 days; 515, 756, 1110 mg/kg: 10/10 after 14 days
- Clinical signs:
- other: dyspnea, apathy, staggering, exsiccosis, diarrhea
- Gross pathology:
- - heart : acute dilatation biateral, acute congestive hyperemia;
- stomach : dilated, liquid content;
- urinary bladder: in several animals remarkable filling;
- intestinal mucosa : slight reddened, atonic, diarreic content.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
