Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientiffically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
13319-75-0
Cas Number:
13319-75-0
IUPAC Name:
13319-75-0
Constituent 2
Reference substance name:
boron trifluoride dihydrate
IUPAC Name:
boron trifluoride dihydrate
Details on test material:
- Name of test material (as cited in study report): borfluorid-Dihydrat

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
A standardized animal laboratory diet was used.

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:
The test substance was administered in concentrations of 2.15, 3.16, 4.64 and 6.81% (V/V)
Doses:
351, 515, 756, 1110 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 326 mg/kg bw
Remarks on result:
other: original value : ca. 200 ul/kg
Mortality:
351 mg/kg: 6/20 after 14 days; 515, 756, 1110 mg/kg: 10/10 after 14 days
Clinical signs:
other: dyspnea, apathy, staggering, exsiccosis, diarrhea
Gross pathology:
- heart : acute dilatation biateral, acute congestive hyperemia;
- stomach : dilated, liquid content;
- urinary bladder: in several animals remarkable filling;
- intestinal mucosa : slight reddened, atonic, diarreic content.

Applicant's summary and conclusion