Registration Dossier
Registration Dossier
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EC number: 231-569-5 | CAS number: 7637-07-2
Endpoint summary
Administrative data
Description of key information
The LC50/4hours is 1210 mg/m3 in rats (Rusch, 1986). Animals mainly exhibited typical clinical signs of respiratory distress.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 326 mg/kg bw
- Quality of whole database:
- according to a BASF study (1978) for the classification of Boron trifluoride dihydrate.
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 210 mg/m³ air
Additional information
The LC50/4 hours was calculated to be around 1210 mg/m3 when rats were whole body exposed by inhalation to aerosols of BF3 dihydrate (Rush, 1986). The animals exhibited typical signs of respiratory distress including gasping, lacrymation, nasal and oral discharge. Quite similar range of LC50 were reported in rats : LC50/4hours of 1180 mg/m3 (Kasparov, 1972) and LC50/1 hour of 820.4 -1313 mg/m3, indicative that the substance has a high potential of acute toxicity by inhalation.
The NOAEL for respiratory irritation following a single exposure of 4 hours to low dose levels was estimated around 24.6 mg/m3 (Rush, 2008).
Justification for classification or non-classification
According to EU directive 67/548/EEC, the substance should be classified as toxic by inhalation instead of very toxic by inhalation. According to EU Regulation (EC) N0. 1272/2008 (CLP) BF3 should be classified acute toxicity category 3 regarding the LC50/4 hours of about 1000 mg/m3 for exposure to aerosols of BF3. Nevertheless, the current classification (acute toxicity category 2) is not challenged.
According to a BASF study dated 1978, a classification acute toxicity category 4 H302, EU Regulation (EC) N0. 1272/2008 (CLP) is applied for the oral route for the boron trifluoride dihydrate form.
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