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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-12-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
Deviations:
no
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.01
pH:
6.5
Remarks on result:
other: Temperature not specified
Details on results:
- Dead time t0: 2.448 min
- Retention time of reference substances and test item: The average retention time of Phenol, Acetophenone, Methyl benzoate, Ethyl benzoate, Naphthalene and Phenanthrene in the reference substances mixture solution was 3.458 min, 4.084 min, 5.514 min, 7.310 min, 13.446 min and 32.038 min separately. The retention time of test item were 4.682 min and 4.699 min respectively.
Conclusions:
Based on the test results, the Pow of test item was 102.3, lgPow was 2.01 (pH=6.5).
Executive summary:

The Partition Coefficient (n-octanol/water) of test item was determined compatible with OECD 117, High Performance Liquid Chromatography (HPLC) Method. Based on the test results, the Pow of test item was 102.3, lgPow was 2.01 (pH=6.5).

Description of key information

The Pow of test item was 102.3, lgPow was 2.01 (pH=6.5).

Key value for chemical safety assessment

Log Kow (Log Pow):
2.01

Additional information

The Partition Coefficient (n-octanol/water) of test item was determined compatible with OECD 117, High Performance Liquid Chromatography (HPLC) Method.

Based on the test results, the Pow of test item was 102.3, lgPow was 2.01 (pH=6.5).