2-Hydroxypropyl-β-cyclodextrine ethers

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

GLP compliance:

yes

Type of method:

capillary method

Test material

Test material information

Constituent 1

Reference substance name:

.beta.-Cyclodextrin, 2-hydroxypropyl cycloheptaamylose

IUPAC Name:

.beta.-Cyclodextrin, 2-hydroxypropyl cycloheptaamylose

Constituent 2

Reference substance name:

-

EC Number:

420-920-1

EC Name:

-

Cas Number:

128446-35-5

Molecular formula:

Hill formula: (C42H70-nO35)(C3H7O)n; n(mittel)=5,25

IUPAC Name:

5,10,15,25-tetrakis(hydroxymethyl)-40,44,47,49-tetrakis(2-hydroxypropoxy)-20,30,35-tris[(2-hydroxypropoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2³,⁶.2⁸,¹¹.2¹³,¹⁶.2¹⁸,²¹.2²³,²⁶.2²⁸,³¹]nonatetracontane-36,37,38,39,41,42,43,45,46,48-decol

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Physical Appearance: white powder
Batch No.: 01 (DRD#: SIETS 96.010)
Purity: 89.16%
Water Solubility: >= 180 g/L at 20 °C (SLI Report #97-10-7113)
Density: 991 kg/m³ (0.991 g/cm³) at 24.9 °C (SLI Report #97-4-6948)
Storage conditions: room temperature in a dark, ventilated cabinet

Results and discussion

Melting / freezing point

Melting / freezing pt.:

301 - 308 °C

Atm. press.:

1 013 hPa

Decomposition:

yes

Decomp. temp.:

305 °C

Remarks on result:

other: Standart Deviation: 3.51

Any other information on results incl. tables

at standard temperature and pressure

Applicant's summary and conclusion

Executive summary:

Information on physical and chemical characteristics of a test substance is required to support registration of products in OECD and EC countries. This report describes the determination of the melting point/melting range for hydroxypropylated .beta.-cyclodextrin following OECD Guideline. The melting temperature or melting point is the temperature at which a substance changes its physical state from a solid to a liquid at normal atmospheric pressure. It can be a measure of a substance's purity, and is important for identification purposes. Information on the physical state of a chemical in the environment, as solid, liquid, or gas, is needed to assess the movement and fate of the chemical as well as potential human and environmental exposure.

The study was initiated on 7 April 1997; the day the Study Director signed the protocol, and terminated on the day the Study Director signed the final report. The experimental phase of this study was conducted on 11 April 1997 at Springborn Laboratories, Inc. (SLI), Wareham, Massachusetts. All original raw data and the final report produced during this study are stored in

Springborn's archives at the above location.