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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Gould, S. and R. C. Scott (2005). "2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review." Food Chem Toxicol 43(10): 1451-1459.

"A separate oral study in rats was also conducted by Gerloczy et al. (1990) and showed that up to 6% of a sin gle oral dose was absorbed from the gastrointestinal tract within 5 min. Of the dose administered, approximately 3% was eliminated by the kidney in the urine and 70% in the faeces within 72 h. This finding concurs with Monbaliu et al. (1990) data following oral administration. Analysis of exhaled air showed that 3% of the total dose was metabolised. Tissue distribution analysis showed that the largest amounts of HP-b-CD were detected in the liver (3–5% of the dose) and kidneys (0.2–0.35%) (Gerloczy et al., 1990), suggesting that there may be a slight difference in distribution depending
upon the route of administration; Monbaliu et al. (1990) had shown the kidney as the major organ containing HP-b-CD following intravenous administration"

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):

Additional information