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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
GLP compliance:
yes
Type of method:
sieving
Type of distribution:
mass based distribution

Test material

Constituent 1
Reference substance name:
.beta.-Cyclodextrin, 2-hydroxypropyl cycloheptaamylose
IUPAC Name:
.beta.-Cyclodextrin, 2-hydroxypropyl cycloheptaamylose
Constituent 2
Chemical structure
Reference substance name:
-
EC Number:
420-920-1
EC Name:
-
Cas Number:
128446-35-5
Molecular formula:
Hill formula: (C42H70-nO35)(C3H7O)n; n(mittel)=5,25
IUPAC Name:
2-Hydroxypropyl-.beta.-cyclodextrine ethers
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Physical Appearance: white powder
Batch No.: 01 (DRD#: SIETS 96.010)
Purity: 89.16%
Water Solubility: >=180 g/L at 20 °C (SLI Report #97 -1 0-7113)
Density: 991 kg/m³ (0.991 g/cm³) at 24.9 °C (SLI Report #97-4-6948)
Storage conditions: room temperature in a dark, ventilated cabinet

Results and discussion

Particle size
Key result
Percentile:
D50
Remarks on result:
other: 0.0745 ± 0.0486 mm (length) by 0.0462 ± 0.0331 mm (width)(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Particle size distribution at different passagesopen allclose all
No.:
#1
Size:
2 mm
Distribution:
> 0 %
Remarks on result:
other: Representative Particle Size Range: >2.0 mm
No.:
#2
Size:
1 mm
Distribution:
< 0.1 %
Remarks on result:
other: Representative Particle Size Range: 1.0-2.0 mm
No.:
#3
Size:
0.5 mm
Distribution:
0.4 %
Remarks on result:
other: Representative Particle Size Range: 0.500-1.0mm
No.:
#4
Size:
0.212 mm
Distribution:
10.7 %
Remarks on result:
other: Representative Particle Size Range: 0.212-0.500mm
No.:
#5
Size:
0.125 mm
Distribution:
23.7 %
Remarks on result:
other: Representative Particle Size Range: 0.125-0.212mm
No.:
#6
Size:
0.075 mm
Distribution:
25.3 %
Remarks on result:
other: Representative Particle Size Range: 0.075-0.125 mm
No.:
#7
Size:
0.063 mm
Distribution:
9.37 %
Remarks on result:
other: Representative Particle Size Range: 0.063-0.075 mm
No.:
#8
Size:
0.045 mm
Distribution:
11.7 %
Remarks on result:
other: Representative Particle Size Range: 0.045-0.063 mm
No.:
#9
Size:
other: basin
Distribution:
18.5 %
Remarks on result:
other: Representative Particle Size Range: fines

Any other information on results incl. tables

Microscopic Analysis:

A portion of the test substance was examined under a light microscopic using 40X magnification. The test substance appeared to be a fine, loose powder with no clumping. The test substance was observed to be white with a generally elongated shape. Using a graduated ocular lens, the length and width of 24 particles were measured. The mean ocular length, width and standard deviation (in millimeters) were calculated. The average particle size was calculated to be 0.0745 ± 0.0486 mm (length) by 0.0462 ± 0.0331 mm (width).

Sieve Analysis

Based on the particle size observed in the microscopic analysis, sieve sizes ranging from 2.0 to 0.045 mm were selected.

No hydroxypropylated .beta.-cyclodextrin was retained on the 2.0 -mm sieve. It is recommended in CIPAC Miscellaneous Technique (MT) 58 that personal protective equipment be worn when working with substances with a particle size distribution of this type.

Applicant's summary and conclusion

Executive summary:

This report describes the determination of the particle size of hydroxypropylated .beta.-cyclodextrinusing the dry sieve technique. Particle size between 2.0 to 0.045 mm was measured, and results are reported as the percent of particle retained on each sieve.

Information on the particle size distribution of a chemical in the environment is needed to assess its transport. Test substances with small particle sizes may easily penetrate through soils, whereas large particle sizes may affect the availability of the test substance to terrestrial and aquatic populations as well as affecting the potential biotic and abiotic degradation of the test substance.

The study was initiated on 7 April1997, the day the Study Director signed the protocol, and terminated on the day the Study Director signed the final report. The experimental phase of this study was conducted on 28 April1997 at Springborn Laboratories, Inc. (SLI), located in Wareham, Massachusetts. All original raw data and the final report produced during this study are stored in Springborn's archives at the above location.