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EC number: 420-920-1
CAS number: 128446-35-5
Mean Measured Concentrations of hydroxypropylated
.beta.-cyclodextrin during the Acute Static Toxicity Test with
Nominal Conc. (mg/L)
Measured Conc. (mg/L)
Mean Test Level ± SD = 1084 ± 9.9 mg/L; Mean Spike ± SD = 106 ± 0 %
test article, hydroxypropylated .beta.-cyclodextrin , was tested in
Daphnia magna equivalent to the OECD Guideline Study 202.
The primary objective of this study was to estimate the acute
toxicity of hydroxypropylated .beta.-cyclodextrin to Daphnia magna under
static conditions. The test was designed to yield EC50 values following
24 and 48 hours of exposure and a no-observed effect concentration
(NOEC), if possible. The definitive test was conducted from June 10,
1997, to June 12, 1997.
The definitive study was conducted as a limit test using the
nominal test concentration of 1000 mg/L of hydroxypropylated
.beta.-cyclodextrinalong with a control. Twenty Daphnia magna (five
daphnids in each of the four replicates) were exposed to the control and
test concentration. Samples for analytical confirmation were collected
from each parent solution at 0 hour and from each replicate at 48 hours
of the definitive test. The mean measured test concentration for samples
analyzed at 0 and 48 hours was 1084 mg/L, representing 108% of the 1000
mg/L nominal test concentration.
Water quality parameters of temperature, dissolved oxygen, and pH
were measured 0 and 48 hours of the definitive study and were within
acceptable limits. The temperature of the test solutions ranged from
20.9 to 21.3°C and the dissolved oxygen levels ranged from 7.7 to 8.2
mg/L. The pH of the test solutions ranged from 8.2 to 8.4.
All daphnids in the control and 1000 mg/L nominal test
concentration were normal during the study with no observed abnormal
effects or immobilization. The 24- and 48-hour EC50 values for
hydroxypropylated .beta.-cyclodextrin to Daphnia magna were all
estimated to be greater than the mean measured test concentration of
1084 mg/L. The 48-hour NOEC was determined to be >=1084 mg/L, which was
based on the lack of abnormal effects and immobilization at this
concentration. A slope of the 48-hour dose-response line could not be
calculated since the study was conducted as a limit test. All results
were based on the mean measured concentration.
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