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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

surface tension
Type of information:
experimental study
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
according to guideline
EU Method A.5 (Surface Tension)
GLP compliance:
Type of method:
ring method

Test material

Constituent 1
Reference substance name:
.beta.-Cyclodextrin, 2-hydroxypropyl cycloheptaamylose
.beta.-Cyclodextrin, 2-hydroxypropyl cycloheptaamylose
Constituent 2
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
Hill formula: (C42H70-nO35)(C3H7O)n; n(mittel)=5,25
Test material form:
solid: particulate/powder
migrated information: powder
Details on test material:
Physical Appearance: white powder
Batch No.: 01 (DRD#: SIETS 96.010)
Purity: 89.16%
Water Solubility: >= 180 g/L at 20 °C (SLI Report #97-10-7113)
Density: 991 kg/m³ (0.991 g/cm³) at 24.9 °C (SLI Report #974-6948)
Storage conditions: room temperature in a dark, ventilated cabinet

Results and discussion

Surface tension
Surface tension:
> 63.6 - < 65 mN/m
22 °C
1 g/L

Applicant's summary and conclusion

Since the surface tension of hydroxypropylated .beta.-cyclodextrin was greater than 60 mN/m, hydroxypropylated .beta.-cyclodextrin was not considered to be a surface-active substance.
Executive summary:

Surface tension is the free surface enthalpy per unit of surface area. The surface tension of a liquid (i.e.water) is influenced by the chemical properties of dissolved substances. Substances that are surface active may increase or decrease the surface tension. Knowledge of this property is environmentally relevant for several reasons. Surface-active substances, even at very low concentrations, can produce an increase in the wettability of cell membranes, which may lead to an increase in the toxicity of active substances. At higher concentrations, a surface-active substance can act as an emulsifier. A surface-active substance affects interfacial properties (e.g.,air/water, water/solid), possibly enhancing photodegradation or photoconversion and possibly causing foaming.

Testing procedures for this study were based on the measurement of the maximum vertical force required to separate a measuring body from the surface of that liquid. Surface tension was determined by measuring the force required to withdraw a horizontally suspended ring from a solution ofhydroxypropylated .beta.-cyclodextrinin water.

The study was initiated on 7 April 1997, the day the Study Director signed the protocol, and terminated the day the Study Director signed the final report. The experimental phase of this study was conducted on 24 April 1997 at Springborn Laboratories, Inc. (SLI), located in Wareham, Massachusetts.