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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Respiratory sensitisation

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Administrative data

Endpoint:
respiratory sensitisation, other
Type of information:
other: collection of literature

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
other: Resp. Sens. Cat 1
Remarks:
in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
Conclusions:
Based on the available data, Tosylchloramide sodium needs to be classified as respiratory sensitizer ( Resp. Sens. Cat 1,/ H334) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
Executive summary:

Literature summary on Tosylchloramide sodium and sensitisation:

Tosylchloramide sodium is a known respiratory sensitiser in humans. As all known human chemical respiratory sensitisers elicit positive results in predictive animal tests for contact sensitisation, there is no use in performing such test for Tosylchloramide sodium, which is known to be able to cause IgE mediated occupational asthma (OA). The frequency of occurrence OA by Tosylchloramide sodium is unclear. At immunological investigations proof is found that Tosylchloramide sodium reacts with lysine-containing peptides. Suggesting that Tosylchloramide sodium acts as a hapten (Wass, U. and Belin, L., 1990). Specific IgE–antibodies are found which are directed to the p–toluenesulphonyl group.

In some people with skin reactions, a type IV allergic reaction to Chloramine–T could be seen upon patch testing. A large scale study (Hansen, K. S., 1983) shows that Tosylchloramide sodium rarely causes allergic contact eczema. Additionally Tosylchloramide sodium was tested in t he guinea pig maximization test (GPMT), local lymph node assay (LLNA), and the Buehler test for its potential to cause contact dermatitis and Chloramine-T tested positive in these predictive test for sensitization (Basketter, D.A., et al., 1996;Basketter, D.A., et al., 1999; Kimber, I., et al., 1994).

Based on the available data, Tosylchloramide sodium needs to be classified as respiratory sensitizer ( Resp. Sens. Cat 1,/ H334) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).