Registration Dossier
Registration Dossier
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EC number: 204-854-7 | CAS number: 127-65-1
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2007
- Justification for type of information:
- Study showed that the test substance degrades in n-hexane and 2-propanol therefore a study to determine the stability in organic solvents could not be performed.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guidelin 105
- Deviations:
- yes
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EC Method A.2
- Deviations:
- yes
- Principles of method if other than guideline:
- Method: adpoted OECD Guideline 105 and EC A.2.
- GLP compliance:
- yes (incl. QA statement)
- Medium:
- other: Organic Solvents
- Test substance stable:
- no
- Details on results:
- For raw data see Table
- Conclusions:
- Study showed that the test substance degrades in n-hexane and 2-propanol therefore a study to determine the stability in organic solvents could not be performed.
- Executive summary:
- The solubility of the test item Tosylchloraminde sodium, trihydrate in n-hexane and 2-propanol, following the adopted guidelines OECD 105 (1995) and EC A.2 (1992), could not be determined, since the test item was not stable in n-hexane and 2-propanol over a period of 96 h at room temperature.
Reference
The solubility of Halamid in n-hexane and 2-propanol could not be determined due to degradation of the test item in the solvents.
| n-hexane | 2 -propanol | |||
| time (h) | peak area (mAU*s) | Content (%) | peak area (mAU*s) | Content (%) |
| 0 | 839.25024 | 100 | 871.09033 | 100 |
| 2 | 768.78040 | 92 | 662.60217 | 76 |
| 24 | 719.62781 | 86 | 230.26199 | 26 |
| 96 | 577.27808 | 69 | 0 | 0 |
Description of key information
WAIVER - Study could not be performed: substance is not stable in organic solvents.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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