Registration Dossier
Registration Dossier
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EC number: 202-809-6 | CAS number: 100-00-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimentelle Untersuchung der allergenen Wirkung von Ortho- und Para-nitrochlorbenzol.
- Author:
- Rusakov NV, Korotkova GI, Biklubatov VS (1973)
- Year:
- 1 973
- Bibliographic source:
- Gig Sanit 3: 13-16
Materials and methods
- Principles of method if other than guideline:
- 3 drops of a 1 % solution to the clipped area of the skin for 5 d; on d7 1 drop of the 1 % solution to an untreated area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Draize test
- Justification for non-LLNA method:
- modified Draize test
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Para-nitrochlorbenzol
- Analytical purity: no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: epicutaneous, 1% solution in aceton
- Vehicle:
- other: acetone
- Concentration / amount:
- 1%
Challenge
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 1%
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 1 % 2nd application: Challenge 1 %
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Group:
- test chemical
- Remarks on result:
- not measured/tested
- Reading:
- 2nd reading
- Group:
- test chemical
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
No more data given
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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