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Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: adopted according to OECD SIDS, peer reviewed data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2003
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
number of animals which show effects is missing
Principles of method if other than guideline:
Method: other: head-only exp., atmosph. contained vapor and micro-
crystalline particles (particle size: 2.7 up to greater 90 µm, respirable fraction: 6.8 to 92.3 %), 16100 mg/m³ was the highest attainable concentration
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-4-nitrobenzene
EC Number:
202-809-6
EC Name:
1-chloro-4-nitrobenzene
Cas Number:
100-00-5
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-4-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: 99.2 %

Test animals

Species:
rat
Strain:
other: Crl:CD
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
head only
Vehicle:
other: air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
2.63, 2.84, 3.27, 3.35, 3.73, 6.12, 9.47, 16.1 mg/l (approx. 2630, 2840, 3270, 3350, 3730,6120, 9470, 16100 mg/m³)
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LCLo
Effect level:
ca. 16 100 mg/m³ air
Exp. duration:
4 h
Mortality:
at 16100 mg/m3: 1/10 3 days post exposure
Clinical signs:
other: during and immediately following exposure: cyanosis, corneal opacity, abnormal arched-back posture, lethargy, reddish-brown nasal and frothy mouth discharges,tachypnea, semi-prostration   -  from 1 - 14 days post-exposure: pallor, lacrimation, alopecia, c
Body weight:
weight loss: 6-13 % within the first 24 hours with normal gain thereafter

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LCLo (inhalation) = 16100 mg/m3 air
Classification:
GHS: Acute Inhalation Category 4
Executive summary:

Dupont, 1981

The acute inhalative toxicity of 1-chloro-4-nitrobenzene was investigated in study comparable to OECD guideline 403 with acceptable restrictions. Rats were exposed head-only to an atmosphere containing vapour and microcrystalline particles up to 16100 mg/m³ air for 4 hours. Clinical signs of toxicity were related to dose. During and immediately after exposure cyanosis, corneal opacity, abnormal arched-back posture, lethargy, reddish-brown nasal and frothy mouth discharges, tachypnea, semi-prostration were observed. From 1 - 14 days post exposure, pallor, lacrimation, alopecia, corneal opacity, stained perineal area, dermal irritations were observed. Also weight loss of 6 - 13 % was detected within the first 24 hours but weight gain normalized therafter. Three days post exposure death occurred at 16100 mg/m³ in 1 of 10 animals. Therefore the LCLo was 16100 mg/m³ air.