1-chloro-4-nitrobenzene

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Toxicity, Biodegradability, and Accumulation of a Number of Cl/N-Containing Compounds for Classification and Establishing Water Quality Criteria

Author:

Canton JH, Slooff W, Kool HJ, Struys J, Pouw TJM, Wegman RCC, Piet GJ

Year:

1985

Bibliographic source:

Regulatory Toxicology and Pharmacology 5, 123-131

Reference 2

Reference Type:

secondary source

Title:

1-CHLORO-4-NITROBENZENE CAS No: 100-00-5 SIDS Initial Assessment Report.

Author:

OECD

Year:

2002

Bibliographic source:

UNEP Publications

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD proposal (1979)

Deviations:

not applicable

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1-chloro-4-nitrobenzene

EC Number:

202-809-6

EC Name:

1-chloro-4-nitrobenzene

Cas Number:

100-00-5

Molecular formula:

C6H4ClNO2

IUPAC Name:

1-chloro-4-nitrobenzene

Details on test material:

- Name of test material (as cited in study report): 1-chloro-4- nitrobenzene
- Analytical purity: > 99.5 % Purity (Origin: Riedel-de Haen AG)

Sampling and analysis

Analytical monitoring:

yes

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Details on test conditions:

open system assumed after stability test (see details on analytical methods).

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

8.9 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2.7 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mobility

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The toxicity of 1-chloro-4- nitrobenzene to the aquatic invertebrate Daphnia magna was evaluated in a 48 h study performed in analogy with the OECD proposal (1979) short-term toxicity tests. The 48h-EC50 was determined to be of 2.7 mg/l for immobilization (Canton et al. 1985).

Executive summary:

The acute toxicity of 1-chloro-4- nitrobenzene to the aquatic invertebrate Daphnia magna was evaluated in a 48 h static test performed in analogy with the OECD proposal (1979) short-term toxicity tests. The 48h-EC50 was determined to be of 2.7 mg/L for immobilization. The results of the test can be considered reliable.