Registration Dossier
Registration Dossier
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EC number: 292-222-1 | CAS number: 90583-23-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2-3 Dec 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- visual check; no analytical determination possible
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- visual assessment of solubility
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- > 600 g/L
- Temp.:
- 20 °C
- pH:
- 4.6
- Details on results:
- pH given for a 10% solution of the test item in water
- Conclusions:
- Interpretation of results: miscible
Reference
The following amounts of the freeze-dry test item were added to 2 g of water:
Experiment |
Weighed sample [g] |
Result |
A |
0.1 |
Liquid, clear |
B |
1.0 |
Liquid, clear |
C |
1.3 |
Gel, white |
D |
1.6 |
Gel, white |
E |
2.0 |
Gel, white |
| F | 3.0 | Gel, white |
While being added to the water, solutions with increasing viscosity were being formed, finally resulting in a paste.
With 3 g of test item (freeze dry) being mixed into 2 g of water, a pastel with a total weight of 5 g was formed. This is equivalent to 60% (w/w) of test item in solution/pastel.
As the density of water will significantly increase with addition of the test item, it can be concluded that water solubility is about 600 g/L, resulting in a paste.
Due to the fact that the formation of the paste is a continuous process and no discrete point can be identified at which dissolution in water switches to gelling, the water solubility can be approximated to > 600 g/L.
Description of key information
> 600 g/L at 20 °C, pH = 4.6
Key value for chemical safety assessment
- Water solubility:
- 600 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the substance was determined according to OECD Guideline 105 (flask method). Paste formation at concentrations > 600 g/L was observed.
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