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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

Currently viewing:

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
Deviations:
yes
Remarks:
: lack of details on test substance
GLP compliance:
no
Type of assay:
other: in vivo chromosome aberration assay

Test material

Constituent 1
Reference substance name:
Sulfuric acid, mono-C12-15-alkyl esters, sodium salts
EC Number:
272-575-8
EC Name:
Sulfuric acid, mono-C12-15-alkyl esters, sodium salts
Cas Number:
68890-70-0
IUPAC Name:
Sulfuric acid, mono-C12-15-alkyl esters, sodium salts

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
According to guideline.

Administration / exposure

Route of administration:
oral: feed
Vehicle:
water
Duration of treatment / exposure:
90 days
Frequency of treatment:
Daily
Post exposure period:
none
Doses / concentrations
Dose / conc.:
1.13 other: % nominal in diet
No. of animals per sex per dose:
6
Control animals:
yes, plain diet
Positive control(s):
Yes.

Examinations

Tissues and cell types examined:
Bone marrow cells
Details of tissue and slide preparation:
SAMPLING TIMES:
after 90 days
Evaluation criteria:
According to guideline.
Statistics:
No.

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Negative controls validity:
not applicable
Positive controls validity:
valid

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative