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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 Oct 2014 - 3 Apr 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The method has limitations if applied to certain substances which may include surfactants.
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
2.187
Temp.:
23.5 °C
pH:
>= 7.02 - <= 7.06

The concentrations of the different test solutions were determined according to the outlined method. The results are listed in the table below; each value represents the mean of a duplicate determination.

Test mixture

Concentration of test item [mg/g], 1-octanol phase

Concentration of test item [mg/g], aqueous phase

Pow

Log Pow

1

5.549

0.1254

44.25

1.646

2

5.538

0.1146

48.32

1.684

3

2.826

0.0378

74.86

1.874

4

2.889

0.0353

81.84

1.913

5

1.480

0.0044

337.1

2.528

6

1.444

0.0043

335.8

2.526

Mean Pow = 153.7 what corresponds to log Pow given above.

Description of key information

log Pow  = 2.187 at 23.5 °C, pH = 7

Key value for chemical safety assessment

Log Kow (Log Pow):
2.187
at the temperature of:
23.5 °C

Additional information

The partition coefficient of the substance was determined using shake-flask method according to OECD Guideline 107.