Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
The substance is not skin irritant and it is not eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
The substance was tested for its skin irritation potential with an in vitro test according to OECD TG 439 Reconstructed human epidermis model. The mean cell viability of test item treated tissues was 73 % after 15 minutes exposure period and 42 hours of post-exposure incubation period. No classification for skin irritation of this substance is required according to the CLP Regulation (EC.n.1272/2008).
Eye irritation
The substance was tested for its eye irritation potential with an in vitro test according to OECD TG 492 Reconstructed human Cornea-like Epithelium (RhCE) test method. After 28 minutes exposure followed by product washing and a post incubation of 120 minutes a residual cell viability (mean of two replicates) of 87.5 % has been quantified for test item. No classification for eye irritation of this substance is required according to the CLP Regulation (EC.n.1272/2008).
Justification for classification or non-classification
According to the OECD TG 439 (EpiSkinTM/MTT Method) the test item is classified not irritant to skin if the mean relative viability is higher than 50 % according to the CLP Regulation (EC n.1272/2008). The substance "Reaction mass of dodecane-1-thiol and tridodecyl trithiophosphite" was tested for skin irritation according to OECD TG 439: the mean cell viability of the test item treated tissues was 73 % and therefore no classification for skin irritation/corrosion is required according to the CLP Regulation (EC n.1272/2008).
According to the OECD TG 492, the test item is classified not irritant to eyes if the mean relative viability is higher than 60 % according to the CLP Regulation (EC n.1272/2008). The substance "Reaction mass of dodecane-1-thiol and tridodecyl trithiophosphite" was tested for eye irritation according to OECD TG 492: the mean cell viability of the test item treated tissues was 87.5 % and therefore no classification is required for eye irritation according to the CLP Regulation (EC n.1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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