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EC number: 233-043-0 | CAS number: 10025-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- Test according to state-of-the-art operating procedures for testing of metal bioelution.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
- Objective of study:
- bioaccessibility (or bioavailability)
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM D5517-07: Standard Test Method for determining the extractability of metals from art materials - ASTM, 2007 (American Society for Testing and Materials).
- Principles of method if other than guideline:
- The release/dissolution of indium from Indium(III) chloride in simulated gastric fluid was measured. The resulting value is termed bio-accessibility, and is defined as the fraction of a substance that is soluble under physiological conditions and therefore potentially available for absorption into systemic circulation. The simulated gastric fluid represents an exposure-relevant exposure route (oral exposure). The compound was introduced as powder in a test item / solution ratio of 200 mg/L during 2 hours.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Indium trichloride
- EC Number:
- 233-043-0
- EC Name:
- Indium trichloride
- Cas Number:
- 10025-82-8
- Molecular formula:
- Cl3In
- IUPAC Name:
- indium trichloride
- Test material form:
- other: solution
- Details on test material:
- - Product name: Indium(III) chloride
- Physical state: solution, Clear, colourless
- Lot/batch No.: UP566
- Expiration date of the lot/batch: stable over time
- Storage condition of test material: room temperature, in the dark
Constituent 1
Results and discussion
- Preliminary studies:
- not applicable
Main ADME results
- Type:
- other: bioaccessibility
- Results:
- gastric fluid (2hours): as %In released of total In content: 102
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- not applicable
- Details on distribution in tissues:
- not applicable
- Details on excretion:
- not applicable
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- not applicable
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- gastric fluid (2hours): as %In released of total In content: 102
Any other information on results incl. tables
Indium(III) chloride, loading 0.2 g/L 2h gastric at pH 1.5 |
|||
Analyte X±σ CV |
|||
Indium (In) |
dissolution |
28333 ± 577 μg/L |
2% |
eluted |
137755 ± 1873 μg/g |
1% |
|
% Indium eluted |
|
102% |
|
X= Average of 3 test vessels (0.2µm filtration)
σ = Standard deviation
CV: Coefficient of variation (%)
Applicant's summary and conclusion
- Conclusions:
- Bio-elution test according to state-of-the-art procedures, useful for determining dissolution capacity of In in gastric fluid.
Interpretation of results: other: High bioaccessibility of In from Indium(III) chloride. The dissolution in gastric fluid is used to estimate bioavailability after oral exposure - Executive summary:
During this study on Indium(III) chloride at a loading of 0.2 g/L in simulated gastric fluid (pH 1.5), it was
shown that significant amounts of indium were measured. For indium an average value of 28333 μg/L In
(CV=2%) or 137755 μg In per g test item was found after 2 hours of extraction. This corresponds with
indium release of 102% (based on the available amount of indium (169 g/L), the density (1.25 kg/L)).
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