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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Acute toxicity of 4-tert-butylcyclohexanol to aquatic organisms was investigated for different trophic levels (algae, invertebrates and fish).

The test conducted with fish resulted in an LC50-value of 17 mg/L after 48 h. However, a 48 h study is not in line with today's standards and is regarded as not sufficient for the evaluation of the influence of p-tert-btuylcyclohexanol on fish. Thus, further calculations using QSAR-models and read-across to a structural analogue of p-tert-butylcyclohexanol, L-menthol (CAS 2216-51-5) were performed. On that basis an LC50-value of p-tert-butylcyclohexanol above 1 mg/L can be assumed. For further calculations (e.g. PNEC-values) the worst-case LC50 of 6.82 mg/L, determined by using the EPIsuite-QSAR is used.

The aquatic toxicity of p-tert-butylcyclohexanol on invertebrates has been evaluated on an acute study on daphnids (Daphnia magna) resulting in an EC50 (48 h) of 46 mg/L (nominal). For algae an ErC50 (72h) of 45 mg/L (mean measured) and a NOErC of 14 mg/L (mean measured) is reported based on growth rate.

The influence of p-tert-butylcyclohexanol on microorganisms was tested in a 3 h respiration test on activated sludge. The EC50 (3 h) was determined to be 225 mg/L (nominal); the NOEC (3 h) and EC10 (3 h) values were 100 mg/L (nominal) and 103 mg/L respectively.