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EC number: 202-676-4 | CAS number: 98-52-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Description of key information
According to a reproductive/developmental toxicity study similar to OECD 414 conducted on an analogue sustance there is no indication that the substance has an effect on fertility. In addition, the available 28-day study (OECD 407) does not indicate adverse effects on reproductive tissues or organs.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
According to a reproductive/developmental toxicity study similar to OECD 414 conducted on an analogue sustance it is concluded that the substance is not selectively toxic to embryo-fetal development and did not result in teratogenicity, even at a maternally toxic dosage. In addition, the available 28-day study (OECD 407) does not indicate adverse effects on reproductive tissues or organs.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 160 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Description of key information
There are currently no studies available to assess the reproductive toxicity of 4-tert-butylcyclohexanol.
On the basis of the results of a reproductive/developmental toxicity study similar to OECD 414 conducted on an analogue substance, a maternal NOAEL has been set up to 160 mg/kg bw/d. The only observation associated with treatment with the test material at this dose-level was moderate excess salivation occurring once in each of two rats. This finding is a common response to a strong tasting substance and was therefore not considered as adverse. The 640 mg/kg bw/d dose-level was associated with body weight losses, reduced body weight gains and feed consumption values.
One female in this dose group was sacrificed due to severe adverse clinical observation. It is unclear whether this death, occurring in a single animal, should be considered as an adverse effect of the test substance.
The developmental NOAEL is also 160 mg/kg bw/d. Transient retardations in foetal development associated with 640 mg/kg bw/d dosage included a significant reduction in foetal body weight and associated significant increases in moderate dilation of the renal pelvis and delayed ossification of the caudal vertebrae, fore- and hind-limb phalanges and hind-limb metatarsals.
Based on the results of this study, 4 -tert-butylcyclohexyl is considered to be not selectively toxic to embryo-foetal developmental and did not result in teratogenicity, even at maternally toxic dosage.
In a GLP Guideline study according to OECD guideline 407 rats were administered 4-tert-butylcyclohexanol via gavage at concentrations of 50, 100 and 300 mg/kg bw/day for 28 days. Gross pathology and histopathology included the determination of testes and epididymides weight as well as examination of testes, epididymides, seminal vesicles, ovaries, vagina and uterus. No changes in absolute or relative testes weight were noted. The relative epididymides weight was significantly increased at the end of the recovery period. However the absolute epididymides weight was not statistically significant increased and there were no accompanied microscopic findings. No gross and histopathological findings were observed in any of the examined reproductive tissues and organs. Therefore, 4-tert-butylcyclohexanol is considered not to have adverse effect on reproductive tissues or organs at concentrations, where systemic toxic effects were present (e. g. clinical signs, effects on neurobehaviour, motoractivity and body weight).
Justification for classification or non-classification
Based on the available information, the test material is not classified according to the annex VI of the Regulation (EC) No. 1272/2008 (CLP) and of the Directive 67/548/EEC.
Additional information
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