Registration Dossier
Registration Dossier
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EC number: 202-676-4 | CAS number: 98-52-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Monographs on Fragrance Raw Materials: 4-tert-BUTYLCYCLOHEXANOL
- Author:
- Opdyke, D.L.J.
- Year:
- 1 974
- Bibliographic source:
- Food Cosmet Toxicol 12: 833
- Reference Type:
- other: Report to Research Institute for Fragrance Materials, Inc.
- Title:
- Report to RIFM, 9. May
- Author:
- Kligman, A.M.
- Year:
- 1 973
- Bibliographic source:
- as cited in Opdyke, 1974
Materials and methods
- Study type:
- other: study on human subjects
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- The test substance was applied at a concentration of 4% in petrolatum to human subjects using an 48 h closed patch test.
- GLP compliance:
- no
- Remarks:
- study performed prior to implementation of GLP
Test material
- Reference substance name:
- 4-tert-butylcyclohexanol
- EC Number:
- 202-676-4
- EC Name:
- 4-tert-butylcyclohexanol
- Cas Number:
- 98-52-2
- Molecular formula:
- C10H20O
- IUPAC Name:
- 4-tert-butylcyclohexan-1-ol
Constituent 1
Method
- Subjects:
- no data
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Details on exposure:
- TYPE OF TEST(S) USED: 48 h closed patch test
ADMINISTRATION
- Type of application: occlusive
- Vehicle / solvent: petrolatum
- Concentrations: 4%
Results and discussion
- Clinical signs:
- No irritation was noted after a 48 h closed patch test with 4% test substance in petrolatum on human subjects.
Applicant's summary and conclusion
- Conclusions:
- No irritation was noted after a 48 h closed patch test with 4% test substance in petrolatum on human subjects.
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