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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Principles of method if other than guideline:
Inhalation risk test, where rats were exposed for 8 h to air saturated with vapour of the test substance at 20 °C.
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP
Test type:
other: inhalation risk test (IRT)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
A saturated vapour atmosphere was generated by passing air through a 5 cm thick layer of test substance at 20 °C.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
ca. 0.221 mg/L (QSAR; Danish EPA Database, 2004; saturated vapour concentration at 20 °C).
No. of animals per sex per dose:
12
Control animals:
not specified
Details on study design:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 0.221 mg/L air
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: max. saturated vapour concentration
Mortality:
No mortality occurred.
Clinical signs:
other: No clinical signs were observed.
Gross pathology:
There were no findings at pathology.

Applicant's summary and conclusion

Conclusions:
No mortality and no systemic effects were noted in rats exposed to a saturated vapour atmosphere (at 20 °C) for 8h. Based on these results, the LC50 value was assumed to be greater than 0.221 mg/L (max. saturated vapour concentration). Only limited information on test method (e.g. test animals, inhalation exposure etc.) is provided and thus documentation is insufficient for assessment.