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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
other: Report to Research Institute for Fragrance Materials, Inc.
Title:
Unnamed
Year:
1973
Report Date:
1973
Reference Type:
secondary source
Title:
Monographs on Fragrance Raw Materials: 4-tert-BUTYLCYCLOHEXANOL
Author:
Opdyke, D.L.J.
Year:
1974
Bibliographic source:
Food Cosmet Toxicol 12: 833

Materials and methods

Principles of method if other than guideline:
6 rabbits were dermally exposed to the test substance.
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
6 animals (overall)
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0/6 rabbits died during the study.
Clinical signs:
No clinical signs of toxicity were observed.

Applicant's summary and conclusion

Conclusions:
An acute dermal toxicity study with 4-tert-butylcyclohexanol revealed an LD50 value > 5000 mg/kg bw for rabbits. No information on test animals or test method (coverage, duration of exposure) is provided and thus, documentation is insufficient for assessment.