Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-803-0 | CAS number: 88-14-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Eye irritation study of test substance
- Author:
- MAK
- Year:
- 1 996
- Bibliographic source:
- MAK,1996
- Reference Type:
- other: Secondary source
- Title:
- Human health tier II assessment: Test chemical
- Author:
- NICNAS
- Year:
- 2 016
- Bibliographic source:
- NICNAS,2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test substance in rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Furfuryl alcohol
- EC Number:
- 202-626-1
- EC Name:
- Furfuryl alcohol
- Cas Number:
- 98-00-0
- Molecular formula:
- C5H6O2
- IUPAC Name:
- furfuryl alcohol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 56 mg
- Duration of treatment / exposure:
- 40 to 64 days
- Observation period (in vivo):
- 40 to 64 days
- Duration of post- treatment incubation (in vitro):
- Not specified
- Number of animals or in vitro replicates:
- Not specified
- Details on study design:
- Not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 40 to 64 days
- Reversibility:
- other: Reversible within 40 to 64 days
- Remarks on result:
- other: Irritating
- Irritant / corrosive response data:
- Irritating
- Other effects:
- The test chemical caused inflammation, mucous secretion, and clouding of the cornea
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- An eye irritation test was conducted in rabbits for test chemical to assess the eye irritation potential.The test chemical caused inflammation, mucous secretion, and clouding of the cornea which was reversible within 40 to 64 days. Based on the ocular lesions caused by the chemical, it was considered as an eye irritant.
- Executive summary:
An eye irritation test was conducted in rabbits for test chemical toassess the eye irritation potential.During the study, approx. 56 mg of test chemical was instilled into the eyes of each rabbitandanimalswere observed for ocular lesions.The test chemical caused inflammation, mucous secretion, and clouding of the cornea which was reversible within40 to 64 days.
Although the effects were reversible butbased on the observed ocular lesions it was considered as irritating to eyes of the treated rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
