Registration Dossier
Registration Dossier
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EC number: 201-803-0 | CAS number: 88-14-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute oral toxicity study of test chemical in mice
- Author:
- E. W. Schafer et. al.
- Year:
- 1 985
- Bibliographic source:
- Arch. Environ. Contain. Toxicol.,1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of test chemical on deer mice (Peromyscus maniculatus).
- GLP compliance:
- no
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 2-furoic acid
- EC Number:
- 201-803-0
- EC Name:
- 2-furoic acid
- Cas Number:
- 88-14-2
- Molecular formula:
- C5H4O3
- IUPAC Name:
- furan-2-carboxylic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material: 2-furoic acid
- IUPAC name: furan-2-carboxylic acid
- Molecular formula: C5H4O3
- Molecular weight: 112.084 g/mole
- Smiles : c1(C(O)=O)ccco1
- Inchl: 1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)
- Substance type: Organic
- Physical state: Solid powder (white)
Constituent 1
Test animals
- Species:
- other: Deer mice
- Strain:
- other: Peromyscus maniculatus
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 1225 mg/kg/day
- No. of animals per sex per dose:
- 2 to 4 animals were used per geometrically spaced dosage level
And
6 to 20 animals per experiment - Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 3 days
- Frequency of observations and weighing:no data available
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No data available - Statistics:
- Thompson (1948) and Thompson and Weil (1952)
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 225 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed in treated deer mice at dose level 1225 mg/kg/day
- Mortality:
- No mortality was observed in treated deer mice at dose level 1225 mg/kg/day
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be >1225 mg/kg/day when deer mice were treated with test chemical orally via gavage over the 3-day test period without killing more than 50% of the test animals.
- Executive summary:
Acute oral toxicity study was done in 2 to 4 deer mice using test chemical .No Mortality was observed at dose 1225 mg/kg/day.Hence,LD50 value was considered to be >1225 mg/kg/day when deer mice were treated with test chemical orally via gavage over the 3-day test period without killing more than 50% of the test animals.
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