Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-803-0 | CAS number: 88-14-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Determination of skin irritation of test chemical
- Author:
- D.L.J. Opdyke
- Year:
- 1 973
- Bibliographic source:
- Food and Cosmetics Toxicology,1973
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Human maximization test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzyl formate
- EC Number:
- 203-214-4
- EC Name:
- Benzyl formate
- Cas Number:
- 104-57-4
- Molecular formula:
- C8H8O2
- IUPAC Name:
- Benzyl formate
- Test material form:
- other: Liquid
- Details on test material:
- -Name of the test material : benzyl formate
-Substance type : Organic
-Physical state : colorless liquid
- Molecular formula: C8H8O2
- Molecular weight : 136.14792 g/mol
- Smiles notation: C1=CC=C(C=C1)COC=O
- Purity : No data available
- Impurities (identity and concentrations): No data available
Constituent 1
Test animals
- Species:
- human
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Age at study initiation:No data available
- Weight at study initiation:No data available
- Housing:No data available
- Diet (e.g. ad libitum):No data available
- Water (e.g. ad libitum):No data available
- Acclimation period:No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C):No data available
- Humidity (%):No data available
- Air changes (per hr):No data available
- Photoperiod (hrs dark / hrs light):No data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- No Data Available
- Duration of treatment / exposure:
- 48 Hrs
- Observation period:
- 48 Hrs
- Number of animals:
- 5 healthy male Humans
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 Hrs
- Reversibility:
- not reversible
- Remarks on result:
- other: No irritation was observed
- Irritant / corrosive response data:
- No irritation was observed.
- Other effects:
- No Data Available
Any other information on results incl. tables
In a preliminary study to a maximization test, a 10% concentration of test chemical in petrolatum was applied under occlusion for 48 h to the back of 5 healthy male patients. There was no irritation observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- In a preliminary study of a human maximization test, a 10% concentration of test chemical in petrolatum was applied under occlusion for 48 h to the back of 5 healthy male patients. There was no irritation observed.
- Executive summary:
In a preliminary study to a maximization test, a 10% concentration of test chemical in petrolatum was applied under occlusion for 48 h to the back of 5 healthy male patients. There was no irritation observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
