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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Determination of skin irritation of test chemical
Author:
D.L.J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology,1973

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Human maximization test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl formate
EC Number:
203-214-4
EC Name:
Benzyl formate
Cas Number:
104-57-4
Molecular formula:
C8H8O2
IUPAC Name:
Benzyl formate
Test material form:
other: Liquid
Details on test material:
-Name of the test material : benzyl formate
-Substance type : Organic
-Physical state : colorless liquid
- Molecular formula: C8H8O2
- Molecular weight : 136.14792 g/mol
- Smiles notation: C1=CC=C(C=C1)COC=O
- Purity : No data available
- Impurities (identity and concentrations): No data available

Test animals

Species:
human
Strain:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data available
- Age at study initiation:No data available
- Weight at study initiation:No data available
- Housing:No data available
- Diet (e.g. ad libitum):No data available
- Water (e.g. ad libitum):No data available
- Acclimation period:No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C):No data available
- Humidity (%):No data available
- Air changes (per hr):No data available
- Photoperiod (hrs dark / hrs light):No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
No Data Available
Duration of treatment / exposure:
48 Hrs
Observation period:
48 Hrs
Number of animals:
5 healthy male Humans
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 Hrs
Reversibility:
not reversible
Remarks on result:
other: No irritation was observed
Irritant / corrosive response data:
No irritation was observed.
Other effects:
No Data Available

Any other information on results incl. tables

In a preliminary study to a maximization test, a 10% concentration of test chemical in petrolatum was applied under occlusion for 48 h to the back of 5 healthy male patients. There was no irritation observed.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
In a preliminary study of a human maximization test, a 10% concentration of test chemical in petrolatum was applied under occlusion for 48 h to the back of 5 healthy male patients. There was no irritation observed.
Executive summary:

In a preliminary study to a maximization test, a 10% concentration of test chemical in petrolatum was applied under occlusion for 48 h to the back of 5 healthy male patients. There was no irritation observed.