α,α,α-trichlorotoluene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Deficiencies: Purity of test substance is not given; small number of animals per group and method does not comply with the current standard (animals skin abraded)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

Benzotrichloride was received from the study´s sponsor on August 31, 1978 (Velsicol Chemical Corporation) as lot: D8-195-1 appearing as transparent yellow liquid with white particles.

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Vehicle:

not specified

Duration of exposure:

24 hours under occlusive conditions

Doses:

1000, 2000, 4000, 8000 mg/kg bw

No. of animals per sex per dose:

2 male and 2 female rabbits per group

Details on study design:

The skin of one male and one female per group was abraded

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

4 000 mg/kg bw

Remarks on result:

other: 95% confidence interval 2681 - 5968 mg/kg bw for males and females combined

Mortality:

4000 mg/kg bw: 1 male (day 3), 1 female (day 6)
8000 mg/kg bw: 2 males (day 2), 2 females (day 3)

Clinical signs:

In males and females of the 4000 mg/kg bw treatment group hypoactivity and ataxia were the most pronounced pharmacotoxic signs. They persisted for the observation period of 14 d.

Body weight:

Starting with 2000 mg/kg bw a weight reduction was observed for female rabbits and also for males and females at 4000 mg/kg bw. This symptom was more pronounced in females.

Gross pathology:

irritation at application site, mottled or pale coloration of livers, brown or green fluid in stomach, brown intestinal contents, lung congestion (females only)