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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Deficiencies: Purity of test substance is not given; small number of animals per group and method does not comply with the current standard (animals skin abraded)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Benzotrichloride was received from the study´s sponsor on August 31, 1978 (Velsicol Chemical Corporation) as lot: D8-195-1 appearing as transparent yellow liquid with white particles.

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Vehicle:
not specified
Duration of exposure:
24 hours under occlusive conditions
Doses:
1000, 2000, 4000, 8000 mg/kg bw
No. of animals per sex per dose:
2 male and 2 female rabbits per group
Details on study design:
The skin of one male and one female per group was abraded

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 000 mg/kg bw
Remarks on result:
other: 95% confidence interval 2681 - 5968 mg/kg bw for males and females combined
Mortality:
4000 mg/kg bw: 1 male (day 3), 1 female (day 6)
8000 mg/kg bw: 2 males (day 2), 2 females (day 3)
Clinical signs:
In males and females of the 4000 mg/kg bw treatment group hypoactivity and ataxia were the most pronounced pharmacotoxic signs. They persisted for the observation period of 14 d.
Body weight:
Starting with 2000 mg/kg bw a weight reduction was observed for female rabbits and also for males and females at 4000 mg/kg bw. This symptom was more pronounced in females.
Gross pathology:
irritation at application site, mottled or pale coloration of livers, brown or green fluid in stomach, brown intestinal contents, lung congestion (females only)

Applicant's summary and conclusion