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EC number: 202-634-5 | CAS number: 98-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Specific investigations
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1977 to Juny 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study very similar to the OECD guideline 401 with no observed deviations and well documented. GLP status unknown. Study considered as comparable to a guideline study with acceptable restrictions, Klimisch 2.c study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- α,α,α-trichlorotoluene
- EC Number:
- 202-634-5
- EC Name:
- α,α,α-trichlorotoluene
- Cas Number:
- 98-07-7
- Molecular formula:
- C7H5Cl3
- IUPAC Name:
- α,α,α-trichlorotoluene
- Details on test material:
- - Name of test material (as cited in study report): benzotrichlorid
- Physical state: liquid colorless with irritating fumes
No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: obtained from Winkelmann, Borchen/Kreis Paderborn
- Weight at study initiation: 160-220g
- Fasting period before study: 16 hours prior the exposure
- Housing: hold in makrolon cages, type III
- Diet (e.g. ad libitum): Altromin R ad libitum
- Water (e.g. ad libitum): water ad libitum
No further data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water and Cremophor EL
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
DOSAGE PREPARATION (if unusual): formulated in water and Cremophor EL
No further data - Doses:
- 50, 500, 1500, 2000, 2500, 3500 mg/kg bw
- No. of animals per sex per dose:
- Fifteen
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations of clinical signs and mortality but no weighing
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, gross pathology of deceased animals.
No further data - Statistics:
- Probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 188 mg/kg bw
- 95% CL:
- 1 993 - 2 411
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 590 mg/kg bw
- 95% CL:
- 1 390 - 1 779
- Mortality:
- cf detailled results
- Clinical signs:
- Reduced activity, scrubby fur, labored breathing, and polyuria with sanguineous urine were observed as toxicological symptoms. Symptoms started within 15 minutes after treatment and persisted for 7 to 9 days.
- Body weight:
- No data
- Gross pathology:
- The gross pathology of deceased animals revealed empty intestinal tracts and white stipples on the stomach mucosa.
- Other findings:
- No data
Any other information on results incl. tables
Detailled results of acute oral toxicity of benzotrichloride for male rats:
Dose (mg/kg bw) | Time point of first deaths | Toxicological results, number of rats: | ||
dead | with intoxication signs | tested | ||
50 | - | 0 | 0 | 15 |
500 | - | 0 | 15 | 15 |
1500 | 24h | 1 | 15 | 15 |
2000 | 24h-4d | 3 | 15 | 15 |
2500 | 24h-2d | 12 | 15 | 15 |
3500 | 7h-24h | 15 | 15 | 15 |
Detailled results of acute oral toxicity of benzotrichlorid for female rats:
Dose (mg/kg bw) | Time point of first deaths | Toxicological results, number of rats: | ||
dead | with intoxication signs | tested | ||
50 | - | 0 | 0 | 15 |
500 | - | 0 | 15 | 15 |
1000 | 3d | 1 | 15 | 15 |
1500 | 24h-2d | 5 | 15 | 15 |
2000 | 24h-2d | 13 | 15 | 15 |
2500 | 24h-2d | 14 | 15 | 15 |
3500 | 7h-24h | 15 | 15 | 15 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information if swallowed Criteria used for interpretation of results: EU
- Conclusions:
- In an equivalent OECD 401 acute oral toxicity test, the authors found a LD 50 of 2188 mg/kg bw for male Wistar rats and a LD 50 of 1590 mg/kg bw for female rats. At this level of information, benzotrichloride should therefore be considered as acute oral toxicant category 4 according to the CLP regulation n° 1272/2008 EC.
- Executive summary:
The acute oral toxicity of benzotrichloride (CAS n° 98 -07 -7) was investigated using male and female Wistar rats (n=15 per sex and dose group) in a test very similar to the OECD guideline 401. The authors treated the rats by gavage with the test substance formulated in water containing Cremophor EL. Mortality and clinical signs were investigated during fourteen days after the exposure. All deceased animals were checked for gross pathology symptoms of intoxication. LD 50 were estimated by probit analysis.
LD50 values of 2,188 and 1,590 mg/kg bw were found for male and female rats, respectively. During the observation period of fourteen days, reduced activity, scrubby fur, labored breathing, and polyuria with sanguineous urine were observed as toxicological symptoms. Symptoms started within 15 minutes after treatment and persisted for 7 to 9 days. The gross pathology of deceased animals revealed empty intestinal tracts and white stipples on the stomach mucosa.
At this level of information, benzotrichloride should therefore be considered as an acute oral toxicant category 4 according to the CLP regulation n° 1272/2008 EC.
The GLP status of this experiment is unknwon but the requirement of the OECD guideline 401 were fulfilled. The study is sufficiently described and should therefore be considered as reliable with restrictions, a Klimisch 2.c study, comparable to a guideline study with acceptable restrictions.
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