3-methylthiazolidine-2-thione

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Version / remarks:

In the Version dated 27-Jul-95

Deviations:

yes

Remarks:

see "Principles of method if other than guideline"

Principles of method if other than guideline:

- Ultra-pure water saturated with n-octanol was used for the stock solution instead of n-octanol saturated with water, because of an easier handling with higher volume accuracy. This had no effect on the
study.
- The shaking time was 23.5 hours instead of 24 hours. This had no effect on the study.

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

mass spectrometry

Key result

Type:

log Pow

Partition coefficient:

0.59

Temp.:

20.3

Remarks on result:

other: no information on pH available

Conclusions:

The GLP study was performed according to OECD TG 107 with acceptable deviations not affecting the study, the results were so obtained via a scientifically reasonable method. Hence, there is no doubt that the obtained results are not reliable: The partition coefficient was determined to be 0.59.

Executive summary:

The partition coefficient of 3-Methyl-thiazolidin-thion-2 was determined in a GLP guideline study according to OECD 107 using the flask method. According to the definition of the OECD-Guideline 107 the test item shows a log Pow of 0.59 with a standard deviation of 0.03.

Description of key information

Partition coefficient: 0.59 [exp. result, OECD 107, flask method, GLP]

Key value for chemical safety assessment

Log Kow (Log Pow):

0.59

at the temperature of:

20.3 °C

Additional information

The partition coefficient of 3-Methyl-thiazolidin-thion-2 was determined in a GLP guideline study according to OECD 107 using the flask method ( with acceptable deviations not affecting the study, the results were so obtained via a scientifically reasonable method). According to the definition of the OECD-Guideline 107 the test item shows a log Pow of 0.59 with a standard deviation of 0.03, not triggering any risks (log Pow < 3; e.g. regarding PBT Assessment).