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EC number: 217-614-1 | CAS number: 1908-87-8
Table 1: Results of the acute toxicity study with vapour
Test item / g
Concentration of test item / mg/m³ air
Vaporising temperature / °C
Test duration / h
Toxicol. Results after 14d*
*1stNumber = Number of dead animals
2ndNumber = Number of animals with symptoms
3rdNumber = Number of animals used
In an acute inhalation toxicity study (similar to OECD 403), groups of Wistar-II rats (10/sex) were exposed by inhalation route to dusts of N-Methyl-2-thion-thiazolidine for 4 hours (inhalation only) at a concentration of 600 mg/m³. Further, Wistar-II rats (20/group), NMRI mice (10/group), Syrian gold hamsters (5/group) and albino rabbits (2/group) were exposed by inhalation route to vapours of N-Methyl-2-thion-thiazolidine for 4 hours (whole body) at concentrations of 137 and 24,725 mg/m³ (rats, mice) and 207 and 24,650 mg/m³. Animals then were observed for 14 days.
LC50 > 600 mg/m³ (dust, rats, m/f)
LC0 ≥ 600 mg/m³ (dust, rats, m/f)
LC0 ≥ 24,725 mg/m³ (vapour, rats, mice)
LC0 ≥ 24,650 mg/m³ (vapour, hamsters, rabbits)
With the dynamic dusting of N-Methyl-2-thion-thiazolidine, an LC50 >600mg/m³ air resulted with a one-time four-hour exposure for male and female rats. With this concentration, no symptoms of poisoning appeared immediately after the exposure or in the following 14-day post-observation time.
When N-Methyl-2-thion-thiazolidine was vaporised (at 100 or 200°C), there were no injuries in the case of rats, mice, rabbits and hamsters through a four-hour exposure.
N-Methyl-2-thion-thiazolidine is classified as being of low toxicity based on the results above and does not trigger classification as acute toxic by inhalation.
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