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EC number: 217-614-1 | CAS number: 1908-87-8
Table Results of the preliminary test (experiments 1 to 6)
pH of buffer solution
pHof test item solution3
Duration in d
At pH 4, 7 and 9 less than 10 % of the test item hydrolysed within 5 days, therefore the test item was hydrolytically stable. No additional testing (Tier 2 and 3) was required.
At pH 4, 7 and 9 less than 10 % of the test item hydrolysed within 5 days. The results for these determinations are summarized below:
Table Summarized results of the preliminary test (tier 1)
pHof buffer solution
Decomposition I (mean value)/ %
The test item was hydrolytically stable. No additional testing (tier 2 and 3) was required.
Hydrolysis of 3-Methyl-thiazolidin-thion-2 at ca 99 - 135mg/L was studied at 50ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9 for 5 days. The experiment was conducted in accordance with EU method C.7 and OECD TG 111, and in compliance with GLP. Samples were analysed at 0 and 5 days, and the test material was analysed by HPLC/UV-Vis.
At pH 4, 7 and 9 less than 10 % of the test item hydrolysed within 5 days, therefore the test item was hydrolytically stable. No additional testing (Tier 2 and 3) was required. This study is classified acceptable and satisfies the guideline requirement for hydrolysis study.
Hydrolysis: Hydrolytically stable based on tier 1 results at pH 4, 7, 9 (OECD 111, GLP)
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