3-methylthiazolidine-2-thione

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-12-09 - 2016-01-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Well documented GLP guideline study according to EU method A.2 and OECD 103 without deviations

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Boiling pt.:

>= 341 - <= 344 °C

Decomposition:

no

Remarks on result:

other: The endothermal effect was seen as boiling.

Boiling point / boiling range: DSC measurement

 

Two DSC measurements in aluminium crucibles with a hole showed an endothermal effect in the temperature range of 65 - 80 °C and a second multistage endothermal effect in the temperature range of 320 - 360 °C. According to the sponsor's information the first endothermal effect was attributed to melting. Thus the second endothermal effect was seen as boiling. The onset temperature (see Table 1) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline. No further endothermic or exothermic effects were observed up to the final temperature (400 °C). The mass loss after the DSC measurements amounted to 100 %.

The results of the DSC measurements are summarized in Table 1.

 

Table 1: Boiling point (DSC measurement)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (boiling) / °C	Onset / °C	Crucible	Observations
35380	8.29	30	400	320 - 360 °C	341.33	Aluminium with a hole	After the measurement the crucible was empty
35381	13.05	30	400	320 - 360 °C	343.59	Aluminium with a hole	After the measurement the crucible was empty

 

The test item had a boiling range of 341 - 344 °C.

Conclusions:

The Boiling point was determined in a GLP guideline study according to OECD 103 and EU method A.2 without deviations on the registered substance itself. Differential Scanning Calometry is a suitable method for boiling point determinations. Hence, there is no indication given that the results are not reliable. Two endothermal effects were seen, the first attributable to the melting point, hence, the other is attributed to the boiling point as no decomposition was noted. In two different runs the boiling point was determined as 341 - 344 °C.

Executive summary:

The boiling point / range of 3-Methyl-thiazolidin-thion-2 was determined in a GLP guideline study according to EU method A.2 and OECD 103 by Differential scanning calorimetry. Two DSC measurements in aluminium crucibles with a hole showed an endothermal effect in the temperature range of 65 - 80 °C and a second multistage endothermal effect in the temperature range of 320 - 360 °C. The first is attributable to the melting point, the second endothermal effect was seen as boiling. The test item had a boiling range of 341 - 344 °C.

Description of key information

Boiling point: 341 - 344 °C [exp. result, OECD 103 and EU method A.2, DSC, GLP]

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

341 °C

Additional information

The boiling point was determined in a GLP guideline study according to OECD 103 and EU method A.2 without deviations on the registered substance itself. Differential Scanning Calometry is a suitable method for boiling point determinations. Hence, there is no indication given that the results are not reliable. Two endothermal effects were seen, the first attributable to the melting point, hence, the other is attributed to the boiling point as no decomposition was noted. In two different runs the boiling point was determined as 341 - 344 °C.

The tonnage driven data requirements under REACH are hence fully met.