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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
One reliable result regarding the analogue of the substance is available. Excretion as indicator of exposure to phthalic anhydride was measured in humans inhaling 0.03-10.5 mg/m3 (Pfaeffli P., 1986). Low exposition (0.15 mg/m3): no phthalic acid excreted; middle exposition (1.63 mg/m3): 1.02 µmol phthalic acid/mmol creatinine. High exposition (10.5 mg/m3): 4.8 µmol phthalic acid/mmol creatinine.

Key value for chemical safety assessment

Additional information

At low atmospheric phthalic anhydride concentrations the excretion of phthalic acid increased from the pre-shift concentration to the post-shift concentration and decreased then until the pre-shift concentration was again reached. The pre-shift phthalic acid concentration in the urine was not significantly different from those of occupationally unexposed people. Exposure to higher concentrations of phthalic anhydride in air resulted in a body load of phthalic acid which was not totally cleared overnight, and with pre-shift phthalic acid concentrations in the urine with a mean value three times the mean control value. Workers occupationally exposed to atmospheric phthalic anhydride absorbed the substance with some being excreted in the urine as unconjugated phthalic acid.